HLA-B27 Antigen

General aspects

HLA (Human Leukocyte Antigen) histocompatibility system is constituted by a
set of molecules placed on the human cells surface stimulating an immune response if recognized as foreign.

HLA system has a foundamental role in graft’s rejection; when receiving a tissue graft, the recipient's immune system will react to and attack the donor tissue unless it expresses the same set of tissue antigens as the recipient's, for which it has learned not to react against.
Through not completely clear mechanism yet, some antingens are able to stimulate an immune response against substances and tissues normally present in the body (autoimmune diseases) leading anatomical and/or functional damage.
Several studies show an association between the HLA-B27 presence and some autoimmune diseases onset, such as spondyloarthritis (ankylosing spondylitis (Fig.1), Reiter syndrome, psoriatic spondyloarthritis ...) and acute anterior uveitis (eye’s inflammation); for example ankylosing spondylitis patients (80-90%) have HLA-B27antigen. In general population the that frequency is variable and it is highest among the Caucasians people (8%).

Genetic test
In Tecnobios Prenatale Eurogenlab is available a genetic test, to determine the alleles presence of 
  Spondilite anchilosante

Fig.1 –

more common HLA-B27antigens.
HLA-B27 DNA test may have a double value, from a side it fits into "preventive medicine" context: knowing an antigen carrier state, that it doesn’t means a disease development, suggests an increased risk and it can be functional in order to take more suitable measures to prevent disease onset. In affected patients, instead, HLA-B27 DNA test could be useful to determine if the pathology is or not HLA-B27 antigen’s presence associated.
Genetic counseling

Tecnobios Prenatale Eurogenlab also provides for a genetic counseling service to inform patients and their families, about of the test result, the risk of a possible disease onset and its family transmission, the diagnosis and treatment likelihood.

Response times

The analysis result is available within 10 working days from draw blood.

Material analyzed

The DNA is extracted from peripheral blood lymphocytes collected in EDTA tubes.


Questo sito usa i cookie per migliorare la tua navigazione. Se vuoi saperne di più o negare il consenso a tutti o ad alcuni cookie clicca qui. Chiudendo questo banner acconsenti all’uso dei cookie. To find out more about the cookies we use and how to delete them, see our privacy policy.

  I accept cookies from this site.
EU Cookie Directive plugin by www.channeldigital.co.uk