HLA (Human Leukocyte Antigen) histocompatibility system is constituted by a
set of molecules placed on the human cells surface stimulating an immune response if recognized as foreign.
HLA system has a foundamental role in graft’s rejection; when receiving a tissue graft, the recipient's immune system will react to and attack the donor tissue unless it expresses the same set of tissue antigens as the recipient's, for which it has learned not to react against.
Through not completely clear mechanism yet, some antingens are able to stimulate an immune response against substances and tissues normally present in the body (autoimmune diseases) leading anatomical and/or functional damage.
Several studies show an association between the HLA-B27 presence and some autoimmune diseases onset, such as spondyloarthritis (ankylosing spondylitis (Fig.1), Reiter syndrome, psoriatic spondyloarthritis ...) and acute anterior uveitis (eye’s inflammation); for example ankylosing spondylitis patients (80-90%) have HLA-B27antigen. In general population the that frequency is variable and it is highest among the Caucasians people (8%).
Tecnobios Prenatale Eurogenlab also provides for a genetic counseling service to inform patients and their families, about of the test result, the risk of a possible disease onset and its family transmission, the diagnosis and treatment likelihood.
The analysis result is available within 10 working days from draw blood.
The DNA is extracted from peripheral blood lymphocytes collected in EDTA tubes.