Prostatic GeneTest

Tecnobios Prenatale Eurogenlab makes available a genetic test to size up a possible
susceptibility to prostate cancer.

Prostatic Gene Test fits inside of an urological path, aiming to the early prostate cancer diagnosis. It consists in a molecular analysis of two single nucleotide polymorphisms (SNPs) of gene HPC2/ELAC2 (hereditary prostate cancer / elaC homolog-2) localized on 17p11 chomosome. Analysed polymorfisms are: Ser217Leu that is a Citosine (C) with Timine (T) nucleotide substitution, so Serine amino acid is changed in Leucine amino acid; and Ala541Thr that is a Guanine (G) with Adenine (A) nucleotide substitution, so Alanine amino acid is changed in Threonine amino acid.
Several research groups study these polymorphisms: some scientific publications show a clear association between some combinations of two polymorphisms genotype and the increase of the prostatic cancer risk (1-5,7) others instead with contrasting results (8-14); that association is underlined by meta-analysis strategies (6,15-17); to date Ser217Leu and Ala541Thr polymorphisms could be considered low penetrance susceptibility markers of prostatic cancer (17,18).

It isn’t a diagnostic test, but it’s a susceptibility test, that is it consider a possible genetic individual predisposition that it increase risk of the pathology development.
Furthermore, the test doesn’t have the negative predictive meaning, that is the absence of Leu217 and Thr541polymorphisms doesn’t meaning there isn’t the risk to develop the prostate cancer, since the pathology etiology is complex and it is not completely clarified and, as several studies showed, it can’t be excluded the involvement of other genes and/or polymorphisms not investigate with Prostatic GeneTest.
Genetic test result must always be illustrated by a Medical Specialist, which is aware of each patient anamnesis and clinical status.

Response time

The analysis result is available within 12-15 working days from draw blood.

Material analyzed

The DNA is extracted from peripheral blood lymphocytes collected through draw blood in EDTA tubes.

Medical Report

It’s possible to view online a medical report after authentication throughout username and password, to download it in pdf format and to print it. Furthermore the medical report has attached a short technical report with a test description and the most important bibliographical reference.

Sources sites
1. Rebbeck TR et al. – Am J Hum Genet (2000)
2. Ostrander EA et al. – Am J Hum Genet (2000) review
3. Tavtigian SV et al. – Nat Genet (2001)
4. Fujiwara et al. J Hum Genet (2002)
5. Stanford JL et al. – Cancer Epidemiol Biomarkers Prev (2003)
6. Camp NJ et al. – Am J Hum Genet (2002)
7. Adler D et al. - J Hum Genet (2003)
8. Rokman et al. – Cancer Res (2001)
9. Suarez BK et al. – Cancer Res (2001)
10. Wang L et al. – Cancer Res (2001)
11. Xu J et al. – Am J Hum Genet (2001)
12. Vesprini D. et al – Am J Hum Genet (2001)
13. Shea PR et al. - Hum Genet (2002)
14. Severi G et al. – J Natl Cancer Inst (2003)
15. Simard J et al. - Endocr Relat Cancer (2003) review
16. Schaid DJ – Hum Mol Genet (2004) review
17. Xu B et al. – Prostate Cancer Prostatic Dis (2010)
18. Kimura T. – Chin J Cancer (2012) review